125 QUESTIONS: WHAT WE DON'T KNOW!

What if a bunch of scientists got together and wrote a list of the most compelling scientific puzzles that can't currently be solved, but have a good chance of being figured out in the next 25 years? Enter the editors of Science Magazine. To celebrate the magazine's 125th birthday, they present 125 questions representing a current survey of "scientific ignorance." The top 25 questions each feature a short essay with an opportunity for readers to reply. Questions include: "What is the biological basis of consciousness?"; "What are the limits of conventional computing?"; "Is an effective HIV vaccine feasible?"; and "Why do humans have so few genes?" For science fans, these questions should stimulate some serious thinking. For scientists, the questions may inspire them to roll up their sleeves and get to work!